Fri Dec 20 2024

157 articles - From Friday Dec 13 2024 to Friday Dec 20 2024

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol

Comments on Treatment Decision for Locally Resected T1 Colorectal Carcinoma Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Acute Severe Ulcerative Colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints.

The expansion of drugs to treat moderate-severe UC over the past decade, particularly the rapidly acting Janus kinase inhibitors, is promising and has reignited the interest in identifying suitable therapeutic candidates for ASUC. Clinical trials in this high-risk population are challenging to conduct and this consensus provides a framework for future trials to advance drug development.

Pubmed   Journal   ReadQx 

Endoscopy

Diagnostic work-up of bile duct strictures: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

In the case of indeterminate biliary strictures, ESGE suggests cholangioscopy-guided biopsies, in addition to standard ERCP diagnostic modalities. Additional intraductal biliary imaging modalities can be selectively used, based on clinical context, local expertise, and resource availability.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

American Society for Gastrointestinal Endoscopy guideline on the diagnosis and management of GERD: summary and recommendations.

In patients with persistent GERD with large hiatal hernias (> 2cm) and Hill grade III or IV, the ASGE suggests either cTIF or surgical therapy based on multidisciplinary review. This document summarizes the methods, analyses, and decision processes used to reach the final recommendations and represents the official ASGE recommendations on the above topics.

Pubmed   Journal   ReadQx 

J Hepatol

EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma.

Key updates from the 2018 EASL guidelines include personalised surveillance based on individual risk assessment and the use of new tools, standardisation of liver imaging procedures and diagnostic criteria, use of minimally invasive surgery in complex cases together with updates on the integrated role of liver transplantation, transitions between surgical, locoregional, and systemic therapies, the role of radiation therapies, and the use of combination immunotherapies at various stages of disease. Above all, there is an absolute need for a multiparametric assessment of individual risks and benefits, considering the patient's perspective, by a multidisciplinary team encompassing various specialties.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Meta-Analysis: Global Prevalence and Mortality of Cirrhosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

This meta-analysis underscores the substantial prevalence of cirrhosis among MASLD patients and highlights significant geographic and demographic variability, calling for improved screening and management strategies.

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Tumor Seeding With Needle Biopsy of Hepatocellular Carcinoma: A Systematic Review.

Overall, the risk of tumor seeding with biopsy of HCC is low.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Clinical, histological and safety outcomes with long-term maintenance therapies for eosinophilic esophagitis: A systematic review and meta-analysis.

Maintenance therapies prevent histological relapse in the long term, without clear disadvantage of dose de-escalation from induction to maintenance phase. Low adverse events and withdrawal rates confirm long-term treatment is well tolerated.

Pubmed   Journal   ReadQx 

Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-Analysis.

HD-DCE is the only modality for IBD surveillance with evidence (low-certainty) demonstrating potential to detect more dysplastic lesions compared to HD-WLE. There was no evidence to support any of the other modalities as an alternative due to very low-certainty evidence.

Pubmed   Journal   ReadQx 

Global epidemiology and characteristics of MASLD in type 1 diabetes mellitus: an updated systematic review and meta-analysis.

MASLD is relatively common in T1DM. Patients with MASLD-T1DM have a distinct clinical profile compared to those with T1DM, with only a small proportion having significant or advanced fibrosis.

Pubmed   Journal   ReadQx 

Predictors of Post-ERCP Pancreatitis: A Comprehensive Systematic Review and Meta-Analysis.

Our meta-analysis focused on adjusted risk factors to provide precise estimates of the most important risk factors for PEP. Incorporating our results into a prediction model may reliably help identify high-risk patients, optimize informed consent, and guide prevention and management strategies for PEP.

Pubmed   Journal   ReadQx 

Endosc Int Open

Validity evidence for endoscopic ultrasound competency assessment tools: Systematic review.

The TEESAT, GAPS-EUS, and EUSAT demonstrate strong validity evidence for formative assessment of EUS and are easily implemented in educational settings to monitor progress and support learning.

Pubmed   Journal   ReadQx   PMC

Gastrointest Endosc

Glucagon-like peptide-1 receptor agonist use and the risk of residual gastric content and aspiration in patients undergoing gastrointestinal endoscopy: a systematic review and a meta-analysis.

GLP-1 RA use was associated with an increased risk of RGC and premature endoscopy termination, but no significant difference was found in the risk of aspiration pneumonia patients undergoing endoscopy.

Pubmed   Journal   ReadQx 

Hepatology

Diagnostic accuracy of 2D-SWE ultrasound for liver fibrosis assessment in MASLD: A multi-level random effects model meta-analysis.

Our meta-analysis identified optimised cut-offs for fibrosis staging by 2D-SWE in etiology-specific chronic liver diseases (MASLD), with excellent diagnostic performance, underscoring the potential for standardising cut-off values.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis.

ESO-101 was superior to placebo in reducing oesophageal eosinophilia. The device was safe and well tolerated in adults with EoE, supporting the continued development of ESO-101 for the treatment of EoE (Trials.gov No. NCT04849390; Eu-CT No. 2020-000082-16).

Pubmed   Journal   ReadQx 

Development and Validation of a Multimodal Machine Learning Model for Diagnosing and Assessing Risk of Crohn's Disease in Patients With Perianal Fistula.

We have developed a multimodal machine learning model and a web tool that can predict and present CD risk in patients initially presenting with perianal fistula.

Pubmed   Journal   ReadQx 

Risk-Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome.

People with diabetes or metabolic syndrome reach risk levels comparable to the average risk population three to four years earlier. Our results offer empirical guidance for defining risk-adapted starting ages of CRC screening for these high-risk groups.

Pubmed   Journal   ReadQx 

Virological and Immunological Characteristics of HBeAg-Positive Chronic Hepatitis B Patients With Low HBsAg Levels.

HBeAg-positive CHB patients with low HBsAg and genotype C exhibited higher noninvasive fibrosis indexes compared with typical patients, accompanied by a significant increase in quasispecies variants associated with preS2 deletion. The emergence of the preS2 deletion mutants in patients could be due to its enhanced ability to evade the host immunity.

Pubmed   Journal   ReadQx 

Am J Gastroenterol

Efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with constipation-predominant irritable bowel syndrome: a single-center, single-blind, randomized controlled trial.

The study manifested that non-invasive taVNS effectively improved constipation and abdominal pain symptoms in IBS-C patients. The alleviation of IBS-C symptoms may be attributed to the integrative effects of taVNS on rectal functions, mediated through vagal, cholinergic, and multi-omics mechanisms.

Pubmed   Journal   ReadQx 

Evaluating Artificial Intelligence-Driven Responses to Acute Liver Failure Queries: A Comparative Analysis Across Accuracy, Clarity, and Relevance.

The study highlights Chat GPT 4 +RAG's superior performance compared to other LLMs. By integrating RAG with LLMs, the system combines generative language skills with accurate, up-to-date information. This improves response clarity, relevance, and accuracy, making them more effective in healthcare. However, AI models must continually evolve and align with medical practices for successful healthcare integration.

Pubmed   Journal   ReadQx 

Proximal polyps are associated with higher incidence of colorectal cancer: Analysis of the Minnesota Colon Cancer Control Study.

Although patients with proximal adenomas were found to have higher hazards of post-colonoscopy CRC, adjusting for polyp multiplicity attenuated the strength of association. Further research is warranted to determine whether polyp location should be factored in the determination of appropriate surveillance intervals.

Pubmed   Journal   ReadQx 

The Role of Gastroesophageal Reflux in Airway Inflammation.

Both experimental and clinical studies have shown that aspirated refluxate can directly damage the airway lining and trigger immune responses that contribute to airway injury and inflammation. While traditional diagnostic tests for gastroesophageal reflux disease can identify abnormal reflux patterns, there is a need for more specific methods to predict airway inflammation or therapeutic outcomes related to reflux aspiration.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

A randomized phase 2 study of efmarodocokin alfa, an IL-22 agonist, versus vedolizumab in patients with ulcerative colitis.

Efmarodocokin alfa did not demonstrate efficacy compared to placebo and this phase 2 study was ended early for futility; however, there was evidence of target engagement (skin AEs, REG3A levels); NCT03558152.

Pubmed   Journal   ReadQx 

Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium.

In hospitalized patients with AKI and cirrhosis, AoCKD was associated with lower 90-day mortality compared to AKI-only. This may be due to the impact of worse liver function parameters in the AKI-only group on short-term outcomes. Further study of the complicated interplay between acute and chronic kidney disease in cirrhosis is needed.

Pubmed   Journal   ReadQx 

Efficacy and Safety of Budesonide Orodispersible Tablets for Eosinophilic Esophagitis up to 3 Years: an Open-Label Extension Study.

Clinical and histological remission of EoE could be maintained with BOT in a large majority of patients for up to 96 weeks, and for up to 144 weeks in patients with uninterrupted BOT therapy across al trials. No additional safety concerns were identified with long-term BOT treatment. (ClinicalTrials.gov, Number NCT02493335).

Pubmed   Journal   ReadQx 

Endoscopic sleeve gastroplasty plus lifestyle intervention in patients with MASH: a multicentre, sham-controlled, randomized trial.

Baseline to end of follow-up changes in body weight, liver tests, liver stiffness(VCTE) and liver histology were recorded RESULTS: Total Body weight loss(TBWL) was 9.47%(±9.38) in ESG group vs 3.91%(±5.43) in ESI group(p 10% we found a significant improvement on NAS score(-4±0.94 vs -0.81±1.62, p<0.01), but not in fibrosis stage(-0.3±1.06 vs -0.59±1.25). Only 2 patients of ESG group had adverse events that required admission that resolved conservatively in 72 hours CONCLUSION: ESG is an effective and safe method to promote weight reduction associated with significant improvement in patients with MASH and obesity.

Pubmed   Journal   ReadQx 

Global Trend of MASH-associated Liver Cancer A Systematic Analysis from the Global Burden of Disease 2021.

Over the past two decades, the burden of MASH-associated PLC has risen, though there are sociodemographic and geographic disparities. This necessitates urgent strategies across the globe to mitigate the epidemic of MASH-associated PLC as well as its metabolic drivers.

Pubmed   Journal   ReadQx 

Hypercoagulation after Hospital Discharge in Acute Severe Ulcerative Colitis: A Prospective Study.

Global measures of haemostasis demonstrated that patients with ASUC were pro-thrombotic compared to controls with quiescent colitis. This difference was maintained 8 to 12 weeks after the initial presentation, supporting clinical observations that patients with ASUC have an elevated risk of VTE after hospital discharge.

Pubmed   Journal   ReadQx 

Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease; a prospective multicenter study.

A substantial proportion of patients with CD exhibited ulcerations in the proximal ileum which correlated with a poorer prognosis. These lesions proved challenging to heal, regardless of the type of biologic used.

Pubmed   Journal   ReadQx 

Lipoprotein (a) in the Full Spectrum of MASLD; Evidence from Histologically and Genetically Characterized Cohorts.

The inverse association observed in cross-sectional studies should be attributed to reverse causality i.e. the presence of liver disease may decrease Lp(a) levels. Genetically predicted very low Lp(a) levels are also associated with impaired liver health prospectively. Clinical trials evaluating Lp(a)-lowering agents should thus be monitored carefully for adverse liver effects in subjects attaining extremely low concentrations.

Pubmed   Journal   ReadQx 

Neighborhood social determinants of health are associated with metabolic dysfunction-associated steatotic liver disease outcomes.

Neighborhood-level SDOH are associated with MASLD burden, comorbidities, and mortality and should be considered in clinical care, quality improvement, and further research.

Pubmed   Journal   ReadQx 

Non-alcohol-related cirrhosis leads to higher 6-week mortality after acute variceal bleeding than alcohol-related cirrhosis.

Patients with non-ALD cirrhosis presenting with AVB had a higher risk of 6-week mortality, at each severity of liver disease by standard indices, than patients with ALD cirrhosis. Cirrhosis etiology (ALD versus non-ALD) should be incorporated into the risk stratification of AVB patients.

Pubmed   Journal   ReadQx 

Non-invasive assessment of portal hypertension in patients with primary biliary cholangitis is affected by severity of cholestasis.

Biochemical-based RESIST criteria demonstrate the highest net benefit compared to elastography-based criteria for ruling out HRV. The severity of cholestasis affects NITs performance to rule out HRV and CSPH in patients with PBC and cACLD.

Pubmed   Journal   ReadQx 

Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-Based Cohort Study 1997-2020.

Approximately one-fourth of individuals with mild UC within one year after diagnosis and half of those with mild CD progressed to moderate-severe disease over time. Young age at diagnosis increased the probability of progression, whereas increasing duration of mild disease decreased the probability.

Pubmed   Journal   ReadQx 

Serum Albumin and Its Trajectory Are Associated with Therapeutic Outcomes in Ulcerative Colitis.

Higher albumin levels were associated with better therapeutic outcomes in patients with UC. However, patients with low but rapidly ascending albumin levels would achieve outcomes comparable to those with medium-to-high levels of albumin.

Pubmed   Journal   ReadQx 

THE OPTIMAL DURATION OF pH-MONITORING: TESTING THE VALIDITY OF LYON 2.0 RECOMMENDATIONS FOR WIRELESS pH MEASUREMENT.

The results of this analysis validate the recommendation that prolonged reflux studies of at least 72-hr duration provide optimal AET measurements for GERD diagnosis. Prolonging studies can also resolve inconclusive results based on 24- and 48-hr studies.

Pubmed   Journal   ReadQx 

Validation and epidemiologic definition of the novel steatotic liver disease nomenclature in a national United States cohort with cirrhosis.

Classification of SLD is highly sensitive to relative weighting of CMRFs and alcohol use. Clinically relevant definitions should consider data availability on alcohol and the limitations of lipid measurements in distinguishing SLD subtypes.

Pubmed   Journal   ReadQx 

Endosc Int Open

Efficacy of anti-obesity medication (AOM) and endoscopic gastric remodeling (EGR): Analysis of combination therapy with optimal timing and agents.

Combining AOM with EGR appears to result in greater weight loss compared with other strategies, with GLP-1RA as the preferred agent and optimal initiation of both therapies occurring within 6 months of each other. Prolonged medication use prior to EGR appears to be associated with suboptimal weight loss, suggesting the importance of early referral for adjunctive therapy.

Pubmed   Journal   ReadQx   PMC

Spinal anesthesia for endoscopic submucosal dissection of large rectosigmoid lesions: Feasibility study.

Our initial experience suggests that SA for ESD of large rectosigmoid LSTs is feasible, and it may prove to be a valuable option, especially for elderly and frail patients.

Pubmed   Journal   ReadQx   PMC

Splenic injury associated with colonoscopy in hospitalized patients: Incidence, risk factors, management, and outcome.

Administrative data analysis suggests that splenic injuries due to colonoscopy are more frequent than previously estimated. Endoscopists should be aware of this rare life-threatening adverse event.

Pubmed   Journal   ReadQx   PMC

Endoscopy

Prophylactic Clip Closure in Preventing Delayed Bleeding After Colorectal Endoscopic Submucosal Dissection on anticoagulants: A multicenter retrospective cohort study in Japan.

Prophylactic complete clip closure after colorectal ESD significantly reduced the DB rate in patients receiving both DOACs and warfarin. It should be performed after ESD, particularly for right-sided lesions.

Pubmed   Journal   ReadQx 

Gastroenterology

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood.

These findings provide fundamental insights into how the gastrointestinal tract modulates emotional behaviors, reveal a novel gut-targeted therapeutic approach for mood modulation, and suggest a new link in humans between in utero SSRI exposure and DGBI development.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Clinical Insights and Management Strategies for Acute Obstructive Suppurative Pancreatic Ductitis: A Retrospective Study of 82 Rare Cases.

AOSPD primarily affects middle-aged and elderly males with chronic pancreatic disease and prior pancreaticobiliary intervention. Imaging and pancreatic juice culture aid diagnosis. Compared to acute-on-CP, AOSPD with CP displays distinct clinical characteristics. Timely and accurate diagnosis and treatment can lead to favorable short-term outcomes for patients with AOSPD.

Pubmed   Journal   ReadQx 

Improvement in Obesity-Related Comorbidities 5 Years After Endoscopic Sleeve Gastroplasty: A Prospective Cohort Study.

ESG is an effective, noninvasive monotherapy that improved markers of hypertension, diabetes, MASLD, and led to total body weight loss of 11.8% at five years post-procedure.

Pubmed   Journal   ReadQx 

Management of ERCP-related perforation: a large multicenter study.

Diagnosing a perforation during the ERCP procedure can prevent serious complications. Fluoroscopic and endoscopic images should be carefully reviewed. Endoscopic management should be the treatment of choice for patients diagnosed with perforation during ERCP procedures.

Pubmed   Journal   ReadQx 

Gut

Early detection of colorectal cancer using aberrant circulating cell-free mitochondrial DNA fragmentomics.

In conclusion, based on aberrant ccf-mtDNA fragmentomic features, a novel and non-invasive approach was established for the detection of patients with early-stage CRC or AA, with high performance.

Pubmed   Journal   ReadQx 

Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn's disease: post hoc analysis of the RISK study.

Early anti-TNF therapy prevents perianal fistula development, especially among patients at increased risk.

Pubmed   Journal   ReadQx 

Hepatic TM6SF2 activates antitumour immunity to suppress metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma and boosts immunotherapy.

Hepatic TM6SF2 protects against MASLD-HCC and activates cytotoxic CD8 + T cells via NF-κB-IL-6 axis. TM6SF2 is a promising strategy for sensitising MASLD-HCC to immunotherapy.

Pubmed   Journal   ReadQx 

Hepatology

Enhancing HBV-specific T cell responses through a combination of epigenetic modulation and immune checkpoint inhibition.

The combination of DAC/αPD-L1 shows promise in improving HBV-specific T cell responses in vitro, highlighting the potential of remodeling exhaustion-associated epigenetic signatures to enhance HBV-specific T cell restoration and suggesting a novel immunotherapeutic avenue for CHB.

Pubmed   Journal   ReadQx 

Interleukin 8-CXCR2 mediated neutrophil extracellular trap (NET) formation in biliary atresia associated with NET-Induced stellate cell activation.

BA patients have persistent IL-8-CXCR2-mediated NETosis that correlates with biomarkers of injury and fibrosis and NETs induce stellate cell activation, suggesting a role for NETs in the immunopathogenesis of disease. Future investigations should focus on therapeutic agents that inhibit NETs in BA.

Pubmed   Journal   ReadQx 

International trends in biliary tract cancer-related mortality, 2000-2022: An observational study of the World Health Organization mortality database.

Although internationally estimated BTC-associated ASRs showed a stable trend over the last two decades, a large increase in estimated iCCA-associated ASRs necessitates developing effective screening for high-risk individuals and disease management strategies.

Pubmed   Journal   ReadQx 

Lhx2 specifically expressed in hepatic stellate cells promotes liver regeneration and inhibits liver fibrosis.

We demonstrated that Lhx2 had pro-regenerative and anti-fibrogenic functions, and elucidated its regulatory mechanism. The study provided a potential target with dual effects for treating liver diseases.

Pubmed   Journal   ReadQx 

Plasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis.

Plasma FSTL-1 has high diagnostic accuracy and could potentially reduce the need for liver biopsy in identifying patients with advanced liver fibrosis.

Pubmed   Journal   ReadQx 

Validation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: Correlation with risk of hepatic decompensation and death.

The Baveno VII "Rule-of-Five" criteria provide a valid system for stratifying risks of death and hepatic decompensation and should be used routinely in patients with chronic liver disease. Among patients with CSPH (LS ≥25 kPa), the subgroup with LS 50-75 kPa ("critical" CSPH) has approximately double the risk of death and hepatic decompensation than LS 25-49.9 kPa.

Pubmed   Journal   ReadQx 

Value of HCC surveillance in a landscape of emerging surveillance options: Perspectives of a multi-stakeholder modified delphi panel.

The panel acknowledged performance metrics of emerging methods may differ from other cancer screening programs given differences in populations, including higher risk of cancer development and competing risk of morality, and differences in diagnostic workflow in patients at risk of HCC. These data provide insights into the perceived value of HCC surveillance in an era of emerging blood- and imaging-based surveillance strategies.

Pubmed   Journal   ReadQx 

J Hepatol

A new generation of non-invasive tests of liver fibrosis with improved accuracy in MASLD.

FIB-12, outperformed al other NITs. FIB-9 is suitable for screening and FIB-11 or FIB-12 for diagnosis.

Pubmed   Journal   ReadQx 

A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease.

Our findings provide an in vivo function of rt-circRNA RCRIN, show its inhibitory effects in MASLD pathogenesis, indicating RCRIN and RPL8 may be therapeutic targets and candidate nucleic acid drugs for treating MASLD. Impact and implications Our finds reveal a novel mechanism connecting a read-through circRNA RCRIN, ribosome heterogeneity and MASLD pathogenesis. In normal hepatocytes, RCRIN exerts its role by reducing liver lipid accumulation and ER stress through promotion of RPL8 degradation. In MASLD patients, lower RCRIN releases RPL8 to form RPL8-contained ribosomes to promote lipid accumulation and ER stress. RCRIN overexpression and RPL8 depletion dramatically suppresses MASLD development and progression. Our findings indicate that RCRIN and RPL8 might be potential therapeutic targets for treatment of MASLD patients.

Pubmed   Journal   ReadQx 

All-cause and cause-specific mortality in patients with chronic hepatitis B and concurrent steatotic liver disease.

Among patients with CHB and SLD, metabolic burden dose-dependently increases the all-cause, liver-related, and cardiovascular mortality risks. Patients with SLD have a lower mortality risk than those without SLD. Identifying these metabolic dysfunctions is crucial for stratifying the level of risk in daily care. Impact and implications Concurrent steatotic liver disease (SLD) is prevalent among patients with chronic hepatitis B (CHB); however, the effects of the associated cardiometabolic risk factors on all-cause and cause-specific mortality remain unknown. This study demonstrated that cumulative metabolic burden dose-dependently increased the risks of all-cause, liver-related, and cardiovascular mortality in patients with CHB and SLD. Moreover, new-onset diabetes mellitus, hypertension, and weight gain during the follow-up period further exacerbated these risks. However, patients with SLD had a lower risk of mortality than those without SLD. Thus, routine screening and monitoring of metabolic dysfunctions constitute a key element of daily care for patients with CHB.

Pubmed   Journal   ReadQx 

Carvedilol vs. propranolol for the prevention of decompensation and mortality in patients with compensated and decompensated cirrhosis.

Our data endorse the current recommendation favoring the use of carvedilol in the prevention of a first decompensation of cirrhosis and suggest extending the recommendation for its preferential use to patients with decompensated cirrhosis without recurrent or refractory ascites. Impact and implications This study addresses a gap in the comparative effectiveness of classical non-selective beta-blockers (e.g., propranolol and nadolol) versus carvedilol in managing cirrhosis in both compensated and decompensated stages. Our results support the preferential use of carvedilol in both settings due to its superior efficacy in reducing first and further decompensation. However, the retrospective nature of the study and inherent selection biases advise caution against broadly applying these findings to patients with decompensated cirrhosis who exhibit signs of circulatory dysfunction or recurrent/refractory ascites.

Pubmed   Journal   ReadQx 

Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs.

Pregnancy MDC exposures may increase risk for liver injury and steatosis, particularly in children. Adequate FA supplementation and maternal cobalt levels may attenuate these associations. Impact and implications The effects of environmental chemical exposures on steatotic liver diseases are not well understood. In a parallel investigation of mothers and children, we found that pregnancy exposures to metabolism-disrupting chemicals may increase the risk for liver injury and steatosis, especially in the child, and that these associations could be attenuated by higher folic acid and/or cobalt levels. These findings can inform policies to decrease environmental chemical pollution and contribute to the design of clinical interventions addressing the MASLD epidemic.

Pubmed   Journal   ReadQx 

Impaired whole blood thrombin generation is associated with procedure-related bleeding in acutely decompensated cirrhosis.

In compensated cirrhosis, WB-TG and PPP-TG do not improve risk stratification. In decompensated cirrhosis, WB-TG may be a promising tool for estimating procedure-related bleeding risk.

Pubmed   Journal   ReadQx 

J Neurogastroenterol Motil

Incidence and clinical course of post-infectious irritable bowel syndrome in patients admitted to university hospitals: 1-year prospective follow-up study.

The incidence of PI-IBS in Korea was relatively low, and most cases improved over time. No risk factors associated with the development of PI-IBS were found. However, persistent diarrhea after enteritis was associated with female sex, EPEC infection, and severe or long-lasting enteritis. IBS symptoms may persist after severe enteritis but usually improve with time.

Pubmed   Journal   ReadQx 

Randomized Multicenter Study to Evaluate the Efficacy and Safety of Fexuprazan According to the Timing of Dosing in Patients with Erosive Esophagitis.

Non-inferiority analysis revealed that taking fexuprazan after meal was non-inferior to taking fexuprazan before meals in patients with EE. The frequency of adverse events was similar between the 2 study groups. The drug is safe and effective for healing EE regardless of the timing of dosing.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Targeting the Future of Eosinophilic Oesophagitis Management.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

A Call to Action: Unraveling the Nuance of Adapted Eating Behaviors in Individuals with GI Conditions.

Further, we address the potential risk factors that gastroenterology clinicians should be aware of when assessing for disordered eating risk reduction. We hope to elucidate the "gray area" related to eating behaviors in patients with known physiological food intolerance such as FODMAP related immune activation in IBS and gluten related reactions in celiac disease in the gut and beyond, that prompt behaviors that are deemed maladaptive in healthy individuals but may be at times adaptive responses in GI conditions.

Pubmed   Journal   ReadQx 

Global Distribution of Colorectal Cancer Staging at Diagnosis: An Evidence Synthesis.

Global disparities in CRC staging exist, indicating a need for targeted interventions to enhance early detection and management, especially in high-metastasis areas.

Pubmed   Journal   ReadQx 

Persistent Lugol-Unstained Lesions: A New Predictor of Progression to Esophageal Squamous Cell Carcinoma?

Pubmed   Journal   ReadQx 

Gastroenterology

Preventing Upper-GI Cancer Mortality through Endoscopy: to Screen or Not to Screen?

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A note from the Editor-in-Chief.

Pubmed   Journal   ReadQx 

Cold snare EMR of large colon polyps: Does one size fit all?

Pubmed   Journal   ReadQx 

Dedicated devices for performance of EUS-guided gastroenterostomy: Are they really needed?

Pubmed   Journal   ReadQx 

Machine-based learning still has a lot to learn.

Pubmed   Journal   ReadQx 

Who should receive and how should we perform transoral incisionless fundoplication for treatment of GERD?

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Appendix Ascariasis.

Pubmed   Journal   ReadQx 

Comments on Limited Sustained Remission After Nucleos(t)ide Analog Withdrawal: Results From a Large, Global, Multiethnic Cohort of Patients With Chronic Hepatitis B (RETRACTB Study).

Pubmed   Journal   ReadQx 

Mast Cell Activation Syndrome and the Triad of MCAS, POTS, and Hypermobile EDS.

Pubmed   Journal   ReadQx 

More Is Not Always Better: Challenging the Dogma of Secondary Prophylaxis for Spontaneous Bacterial Peritonitis.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

A pedigree with CHAPLE disease: variable penetrance and treatment with pozelimab.

Pubmed   Journal   ReadQx 

ASSESSING THE QUALITY OF ARTIFICIAL INTELLIGENCE RESPONSES AND RESISTANCE TO SYCOPHANCY IN PROVIDING PATIENT-CENTERED MEDICAL ADVICE ON GASTROESOPHAGEAL REFLUX DISEASE.

Pubmed   Journal   ReadQx 

An Elusive Pancreatic Mass.

Pubmed   Journal   ReadQx 

An unusual case of multiple gastric masses: granulocytic sarcoma.

Pubmed   Journal   ReadQx 

Functional Lumen Imaging Probe Provides an Accurate Assessment of Esophageal Diameter in Patients with Eosinophilic Esophagitis.

Pubmed   Journal   ReadQx 

HIGH RISK OF DIGESTIVE CANCERS IN PATIENTS WITH CELIAC DISEASE: A NATIONWIDE CASE CONTROL COHORT STUDY.

Pubmed   Journal   ReadQx 

Healthcare and Prescription Medication Affordability for Inflammatory Bowel Disease in the US in 2023.

Pubmed   Journal   ReadQx 

Hepatic artery pseudoaneurysm after Whipple Procedure.

Pubmed   Journal   ReadQx 

Heterozygous variant of CYP2C8*3 is a protective factor for developing post-ERCP pancreatitis.

Pubmed   Journal   ReadQx 

Image and Videos - Clinical Gastroenterology and Hepatology IgG4-related gastrointestinal disease diagnosed by underwater endoscopic mucosal resection.

Pubmed   Journal   ReadQx 

Temporal changes in risk factors of hepatocellular carcinoma in a prospective cirrhosis cohort.

Pubmed   Journal   ReadQx 

Endoscopy

A case of special basket impaction removal during endoscopic retrograde cholangiopancreatography using biopsy forceps under choledochoscope.

Pubmed   Journal   ReadQx   PMC

Artificial intelligence for a rare disease.

Pubmed   Journal   ReadQx 

Bilateral traction method using a clip with thread for rectal endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Combined endoscopic lithotripsy and percutaneous transhepatic cholangioscopy therapy for refractory choledocholithiasis.

Pubmed   Journal   ReadQx   PMC

Comments on "Band-on-band endoscopic variceal ligation: a technique for the treatment of esophageal varices in case of band misplacement".

Pubmed   Journal   ReadQx 

Endoscopic treatment of an unusual post-sleeve gastrectomy complication: first use in clinical practice.

Pubmed   Journal   ReadQx   PMC

Endoscopic ultrasound-guided coil and glue treatment for gastroduodenal artery pseudoaneurysm.

Pubmed   Journal   ReadQx   PMC

Endoscopic ultrasound-guided precise embolization for refractory abdominal arteriovenous malformation.

Pubmed   Journal   ReadQx   PMC

Endoscopy E-Videos - recently published.

Pubmed   Journal   ReadQx 

Foreword Endoscopy - Issue 1.

Pubmed   Journal   ReadQx 

Needle tip insertion technique for accurate and safe puncture in endoscopic ultrasound-guided tissue acquisition.

Pubmed   Journal   ReadQx   PMC

Reintervention using a through-the-mesh technique within the abdominal cavity following stent migration after endoscopic ultrasound-guided hepaticogastrostomy.

Pubmed   Journal   ReadQx   PMC

Successful endoscopic ultrasound-guided fine-needle biopsy of a recurrent paraganglioma using a forward-viewing echoendoscope in a patient who had undergone the Whipple procedure.

Pubmed   Journal   ReadQx   PMC

Technique for stretching a bent guidewire with a biopsy forceps in endoscopic ultrasound-guided hepaticogastrostomy.

Pubmed   Journal   ReadQx   PMC

Transjugular intrahepatic portosystemic shunt combined with endoscopic ultrasonography for portal vein recanalization and biopsy in malignant occlusion of the portal vein.

Pubmed   Journal   ReadQx   PMC

Ultraslim catheter-type peroral cholangioscope-assisted endoscopic transpapillary gallbladder drainage for acute cholecystitis.

Pubmed   Journal   ReadQx   PMC

Underwater endoscopic submucosal dissection using conical hood and gel immersion for esophageal squamous cell carcinoma with anastomotic stricture after total pharyngolaryngectomy.

Pubmed   Journal   ReadQx   PMC

Use of an endoscopic virtual ruler based on the fiber laser principle and artificial intelligence technology.

Pubmed   Journal   ReadQx   PMC

Utility of endoscopic neodymium-iron-boron magnet ring tracer technique in laparoscopy for colorectal lesions.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

A rare case of diarrhea with a rare cause.

Pubmed   Journal   ReadQx 

Challenging Conventional Care: Ethical Considerations of De-intensification of Therapy in IBD.

Pubmed   Journal   ReadQx 

Periprocedural Risks Associated with GLP-1 Receptor Agonists.

Pubmed   Journal   ReadQx 

The Hardy side of H. pylori: uncovering ancient adaptations and host interactions.

Pubmed   Journal   ReadQx 

Use of Fecal Immunochemical Testing (FIT) for risk stratification of patients with symptoms of colorectal cancer referred for diagnostic colonoscopy.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A Biliary Duct Ectopic Pancreas Diagnosed Through Biopsy By Combination of ERCP and a Biliary Imaging System.

Pubmed   Journal   ReadQx 

A rare cause of recurrent acute pancreatitis: a pancreatic neuroendocrine tumor (with video).

Pubmed   Journal   ReadQx 

Endoscopic Resection of Post-Transduodenal Ampullectomy Recurrent Ampullary Adenoma Using Clip-with-Line Traction Method (with video).

Pubmed   Journal   ReadQx 

Endoscopic Ultrasound-Guided Cystocystostomy for Management of Non-Communicating Peripancreatic Fluid Collections.

Pubmed   Journal   ReadQx 

Endoscopic stent placement to treat a colonic diverticulitis with abscess formation(with video).

Pubmed   Journal   ReadQx 

Human acellular dermal matrix for stricture prevention in a patient undergoing circumferential esophageal endoscopic submucosal dissection.

Pubmed   Journal   ReadQx 

Innovative Endoscopic Technique: Pancreaticobiliary Imaging Catheter-Assisted Endoscopic Retrograde Diverticulitis Therapy for Fecalith Obstruction.

Pubmed   Journal   ReadQx 

Metal clip-assisted endoscopic cyanoacrylate injection for duodenal variceal bleeding.

Pubmed   Journal   ReadQx 

One-stop solution: Diagnosis and Treatment of Common Hepatic Artery Pseudoanerysm on Endoscopic Ultrasound.

Pubmed   Journal   ReadQx 

Primary ad-hoc tip-in mucosectomy for colitis-related erythema-like dysplasia.

Pubmed   Journal   ReadQx 

The Gastric "Fog": Re-Emergence of Signet-Ring Cell Carcinoma Amid Helicobacter Pylori Infection.

Pubmed   Journal   ReadQx 

Gut

<i>Faecalibacterium prausnitzii</i>: one species with multiple potential implications in cancer research.

Pubmed   Journal   ReadQx 

Hepatology

Drink less, be your best.

Pubmed   Journal   ReadQx 

From micronutrient to mechanism: Magnesium and the CNNM4 puzzle in alcohol-associated liver disease.

Pubmed   Journal   ReadQx 

Introduction of AASLD's 76th President: Grace L. Su, MD.

Pubmed   Journal   ReadQx 

Letter to the editor: A positive step toward cost-effective and accessible HCC detection awaits further validation.

Pubmed   Journal   ReadQx 

Letter to the editor: The race against time in genetic testing for PALF.

Pubmed   Journal   ReadQx 

Obeticholic acid as second-line therapy for primary biliary cholangitis: Does target trial emulation solve the issue?

Pubmed   Journal   ReadQx 

Putting mean arterial pressure on the map as an AKI biomarker in cirrhosis.

Pubmed   Journal   ReadQx 

Reply: A positive step toward cost-effective and accessible HCC detection awaits further validation.

Pubmed   Journal   ReadQx 

Reply: Can plasma FSTL-1 levels serve as a reliable biomarker for advanced fibrosis?

Pubmed   Journal   ReadQx 

The clot and the complicated consult.

Pubmed   Journal   ReadQx 

Unraveling bile acid dynamics in severe obesity.

Pubmed   Journal   ReadQx 

J Hepatol

Gut bacterial membrane components as pathogenic signalling molecules in PSC-IBD.

Pubmed   Journal   ReadQx 

Hidden metabolic effects of acetyl-CoA carboxylase inhibition.

Pubmed   Journal   ReadQx 

Rifaximin in cirrhosis: Is its microbiological spotless record under threat?

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Increased Prevalence of Visceral Obesity in Nonresponder Patients With Primary Biliary Cholangitis Based on Computed Tomography-Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Increased Prevalence of Visceral Obesity in Nonresponder Patients With Primary Biliary Cholangitis Based on Computed Tomography.

Pubmed   Journal   ReadQx 

Letter: The ESSENCE of Precision in MASH-Strengthening Trial Design for Broader Applicability.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Response to "Recent Advancements and Future Perspectives of Per Oral Endoscopic Myotomy".

Pubmed   Journal   ReadQx 

Gastrointest Endosc

A little confusion about statistical methods and could we believe the results of overfitted logistic regression models?

Pubmed   Journal   ReadQx 

Double-balloon intervention platform in colorectal endoscopic submucosal dissection: What will be its real place outside a randomized trial?

Pubmed   Journal   ReadQx 

EUS-guided gallbladder drainage for patients with antithrombotic therapy: Intervention or medication?

Pubmed   Journal   ReadQx 

Is duodenal papilla radiomics-based prediction model a predictor of post-ERCP pancreatitis?

Pubmed   Journal   ReadQx 

The lack of information on body mass index and the presence of patients with multiple polyps may have affected the result.

Pubmed   Journal   ReadQx 

J Hepatol

Assessment of methods in E1E2 versus E2 immunogen studies for HCV vaccine research.

Pubmed   Journal   ReadQx 

CKM: A New Approach to Managing Metabolic Comorbidities in MASLD?

Pubmed   Journal   ReadQx 

Long-term use of tenofovir disoproxil fumarate and increased fracture risk in elderly patients with chronic hepatitis B: A Sensitivity Analysis Quantifying Effect of Unmeasured Confounding factors on Observational Associations.

Pubmed   Journal   ReadQx 

Not all fat is alike in MASLD.

Pubmed   Journal   ReadQx 

Optimizing Antiviral Prophylaxis Strategies: Insights and Reflections on a Real-World Study.

Pubmed   Journal   ReadQx 

Response to: Sequential therapy with antisense oligonucleotide and immune modulator as a strategy for HBV cure.

Pubmed   Journal   ReadQx 

Revealing Bias in Feature Importance through PLS-DA: A Critical Examination of Machine Learning Applications in Chronic Liver Disease.

Pubmed   Journal   ReadQx 

Sedoanalgesia During TIPS Placement: Balancing Comfort and Safety in Diverse Clinical Settings.

Pubmed   Journal   ReadQx 

The HDL criterion for MetALD can misclassify patients with cirrhosis.

Pubmed   Journal   ReadQx 

Transitions in the nomenclatures for fatty liver disease.

Pubmed   Journal   ReadQx